Curriculum Vitae Publications Research Group PSE

Juergen Hahn Assistant Professor Diploma (1997) RWTH Aachen, Germany M.S. (1998) University of Texas at Austin Ph.D. (2002) University of Texas at Austin Address: Dept. of Chemical Engineering Texas A&M University 3122 TAMU College Station, TX 77843-3122 Phone: (979) 845-3568 Fax: (979) 845-6446 E-mail: hahn@tamu.edu

Research Interests

An effective research program in the systems area is necessarily interdisciplinary in nature. Systems engineering overlaps with applied mathematics and computer science and applications of systems engineering can be found in almost any engineering discipline as well as in physics and biology. The main focus of our research is on developing novel systems engineering techniques for, and applying sophisticated methods to, complex dynamic systems in order to understand their function up to the point that predictions about future behavior under different conditions are possible. The systems under study range from applications in systems biology to traditional chemical engineering processes.

Our research group focuses on two general areas: One is the development of new techniques for systems analysis (e.g., sensitivity analysis, experimental design, parameter estimation, or model reduction) with an emphasis on methods for nonlinear systems and/or significant levels of uncertainty in the model. The second general area is the application of these techniques to specific biochemical systems, such a signal transduction or metabolic pathways, but also to new processes in the chemical process industries, e.g., benzene hydrogenation via reactive distillation. Work conducted in this second area is always performed in close collaboration with other research groups or industry as it is essential to combine any modeling approach with experimental or plant data.

Strong interactions exist between the "methods" and the "application" areas in our group, as certain applications drive the need for new techniques to be developed, while at the same time, it becomes possible to answer specific questions about a system due to newly developed methods. One particularly intriguing aspect is that new systems analysis techniques can be used for different applications with only minor modifications.

Selected Publications

Y. Chu, A. Jayaraman, and J. Hahn. Parameter Sensitivity Analysis of IL-6 Signaling Pathways. IET Systems Biology 1, No. 6, pp. 342-352 (2007)

A.K Singh, A. Jayaraman, and J. Hahn. Modeling Regulatory Mechanisms in IL-6 Signal Transduction in Hepatocytes. Biotechnology & Bioengineering 95, No. 5, pp. 850-862 (2006)

A.K Singh and J. Hahn. Sensor Location for Stable Nonlinear Dynamic Systems: Multiple Sensor Case. Industrial & Engineering Chemistry Research 45, No. 10, pp. 3615-3623 (2006)

C. Sun and J. Hahn. Model Reduction in the Presence of Uncertainty in Model Parameters. Journal of Process Control 16, No. 6, pp. 645-649 (2006)

W.H. Jang, K.R. Hall, and J. Hahn. Genetic/Quadratic Search Algorithm for Plant Economic Optimizations Using a Process Simulator. Computers and Chemical Engineering 30, No. 2, pp. 285-294 (2005)

S. Rajaraman, J. Hahn, and M.S. Mannan. A Methodology for Fault Detection, Isolation, and Identification for Nonlinear Processes with Parametric Uncertainties. Industrial & Engineering Chemistry Research 43, No. 21, pp. 6774 -6786 (2004)